Crosslinking Reagents
Cayman Chemical DehydrolIthocholIc AcId 50mg
A mixture of long-chain fatty acid methyl esters contains six saturated and mono- and poly-unsaturated fatty acid methyl esters intended for use as a reference standard for the detection of fatty acids in corn cottonseed soybean safflower sesame poppy seed walnut kapok and rice oils among others by GC-MS
Cayman Chemical EchInocystIc AcId 50mg
An internal standard for the quantification of aprepitant by GC- or LC-MS
Cayman Chemical E-8-Methyl-6-nonoIc AcId 50mg
A potent inhibitor of MEK5 (IC50 4.3 nM) and moderate inhibitor of ERK5 and TGFBR1 (IC50s 810 and 1800 nM respectively)
Cayman Chemical 1 3 7-TrImethylurIc AcId 50mg
PGF2a 115-lactone is a lipid-soluble internal ester of PGF2a. Hydrolysis of the lactone readily produces free PGF2a in plasma. In rhesus monkeys a total dose of 15 mg of PGF2a 115-lactone terminates early pregnancy whereas PGF2a is ineffective.{4371}
Cayman Chemical OctnoIc AcId-d15 50mg
A fungal metabolite inhibits the growth of HL-60 cells (IC50 20 UM)
Cayman Chemical MIsoprostolfree acId 50mg
An anticoagulant and vitamin K antagonist inhibits VKOR (IC50 1 5 and 5 8 nM for VKORC1 and VKORC1L1 respectively) inhibits a variety of VKOR mutants in cell-based reporter assays (IC50s 0 54-11 21 nM) prolongs prothrombin time in rat blood at 1 5 mg/kg
Cayman Chemical Fmoc-SuccInImIde 25g
A fungal metabolte wth dverse bologcal actvtes nhbts cathepsns B H and L as well as papan fcn and bromelan reduces the autocatalytc actvty of the FMDV leader protease from 0 1-2 mg/ml actve aganst the FCR3 P falcparum stran (C50 836 nM) reduces bone resorpton n embryonc mouse bone explants from 5-25 UM
Cayman Chemical SalvInorIn A PropIonate 10mg
A selective chemical probe for the bromodomain of BRPF1 that displays a TR-FRET pIC50 value of 8 1 and a BROMOscan pKd value of 9 5 shows cellular target engagement with a pIC50 value of 7 7
Cayman Chemical DIsuccInImIdyl Suberate 50mg
A competitive purinergic P2Y1 receptor antagonist (Kb 102 nM) selective for P2Y1 over P2Y2 P2Y4 P2Y6 P2Y12 and P2Y13 as well as P2X1-4 receptors at 10 UM reduces 2-MeSADP-induced PLC activity (IC50 331 nM in turkey erythrocyte membranes) inhibits ADP-induced platelet shape change and aggregation in washed isolated human platelets at 10 UM prolongs the length of tail bleeding time in mice as well as decreases platelet thrombus formation in a mouse model of iron chloride-induced arterial thrombosis at 50 mg/kg
Cayman Chemical QuIlaIc AcId 50mg
A triacylglycerol has been synthesized as a partially hydrogenated confectionery fat when used as 10 of the fat component in cocoa butter it promotes the conversion of low-melting polymorphic forms of cocoa butter-PEP mixtures to high-melting polymorphic forms
Cayman Chemical Halobetasol PropIonate 50mg
A minor metabolite of fenbendazole formed by oxidation of oxfendazole a product of fenbendazole oxidation
Cayman Chemical D-PyroaspartIc AcId 50mg
A SIRT1 activator increases renal SIRT1 activity and protein levels and decreases acetylation of p53 in a mouse model of STZ-induced diabetes as well as in non-diabetic control animals at 100 mg/kg in the diet decreases renal levels of iNOS ROS and MDA as well as the fibrotic markers TGF-B1 and CTGF and the inflammatory markers PAI-1 and VCAM-1 in STZ-induced diabetic mice increases lifespan improves motor function in the balance beam test and reduces atrophy of the neocortex in the N171-82Q mouse model of Huntingtons disease at 0 5 in the diet
Cayman Chemical OrselInIc AcId 50mg
An amine-reactive derivative of rhodamine that is used as a fluorescent label for antibodies and other probes (ex/em max 552/575 nm)
Cayman Chemical Halobetasol PropIonate 10mg
A minor metabolite of fenbendazole formed by oxidation of oxfendazole a product of fenbendazole oxidation